Jamie Connolly, Aaron Myers, Gareth Kerr and Darren Thomas are all injured with Anth Carr still suspended by the club ahead of his RFU hearing next week.
Paul Moss reverts to centre to allow Waites to start at 10. Stu started the season at scrum half, until the Bucks coaches spotted his potential, and he quickly graduated to the Stags where he has put in some excellent performances.
He'll be partnered by Paul Williamson - a late withdrawal last week after injuring his hand at work.
Iain Dixon returns at full back, followinh his knock at Hartpury, with Colin Cheslin resuming on the wing in place of Gareth Kerr.
In the pack Dan Boatman takes a hard earned rest allowing brother Jonny to return to the firstsfor the first time since his horrific ankle injury at Stockport way back in September. Dominic Morrison also starts, with Paul Vinnicombe taking over as skipper.
It's all change but nevertheless a side full of potential. They'll face a Darlington side desperate to kickstart a run-in where they need several victories to give them any chance of not being one of the two level five sides to be relegated under the new league structure.None of the other West sides are in action this weekend.
Firsts away to Darlington. Kick off 3.00 Meet club 12.30 or at Darlington 1.30 I Dixon, C Cheslin, P Hodgson, P Moss, A Cheslin, S Waites, P Williamson, C Stewart, T Sawyer, C Robinson, T Dixon, I Robinson, J Boatman, D Morrison, P Vinnicombe [capt]. Reps: A Coates, D Boatman, G Edwards.|