There will also be a new bench to the one which played a major part in the 42-0 win at Guisborough last week.
The contingent which is at Twickenham to watch England take on Wales is led by skipper Danny Boatman so Stu Waites takes over as skipper. He moves to centre to partner Geeg Edwards with last week's hat trick here Eldon Myers unavailable together with Peter Youll.
Both of last week's winger are also absent so Lewis Wilson and Joe Willis start in place of Scott Butcher and Luke Mallinson. Wilson, of course, scored a tremendous solo try in the warm-up game against Rochdale.
There's less disruption in the pack where Michael Hogan follows his starring role as a replacement prop last week by moving back to partner Owen Bennett in the second row. That allows Chris Atkins to take Danny Boatman's shirt.
On the bench Tom Shaw and Jack Angus provide forward cover with Colts fly half Jonny Heal covering the backs.
The challenge for the new look side is to keep the great run going. So far we have won every game with a try bonus point and have yet to concede a try.
By comparison Northern are second bottom and have yet to win a game or earn a point - despite a better showing in the 37-23 defeat at South Shields Westoe last week. They will, however, be missing Jordan Baggs, who now lives on Tyneside, through injury
West: Zac Southern, Lewis Wilson, Stu Waites, Greg Edwards, Joe Willis, Gavin Painter, Ryan Painter, Adam Coates, Andrew Rollins, Ross Wood Owen Bennett, Michael Hogan, Liam Bailey, Chris Atkins, Sam Miller.
Changes: Tom Shaw, Jack Angus, Jonny Heal
Northern: Jimmy Crowther, Lester Bell, Alex Clark (capt), Paddy Harper, Dom Fawcett, Ben Crossley, Ali Gray, Sam Wilson, Ben Smallwood, Damian Martinez, Dave Snodin,. Jamie Powell, Rob Kinnell, James Nicoll, Tom Schofield.
Changes: Matt Hirst, Donal Collins, Hershall Ward.